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Biochemical and physiological studies on peptides from the elasmobranch gut
Abstract:
A peptide fraction has been purified from intestinal extracts of the dogfish Scyliorhinus canicula which is a powerful stimulant of rectal gland secretory activity. This peptide is distinct from elasmobranch vasoactive intestinal polypeptide (VIP). The elasmobranch VIP fraction is not active in the rectal gland assay and mammalian VIP is only an effective agonist in Squalus and not in Scyliorhinus or Raja. Preliminary characterisation of the elasmobranch VIP indicate that it has strong N-terminal similarities with mammalian VIP but has limited C-terminal comparability. It is suggested that the rectal gland stimulating peptide, rectin, rather than VIP is responsible for the control of fluid and electrolyte secretion of elasmobranchs.