Association of Visceral Obesity Indices With Incident Diabetic Retinopathy in Patients With Diabetes: Prospective Cohort Study
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View abstract on PubMed
Summary
This summary is machine-generated.Visceral obesity, measured by lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese VAI (CVAI), is linked to a higher risk of diabetic retinopathy (DR) in Chinese diabetic patients. Regular monitoring of these visceral obesity indices may aid in DR prevention.
Area Of Science
- Endocrinology and Metabolism
- Ophthalmology
- Public Health
Background
- Visceral adipose tissue is implicated in type 2 diabetes and vascular dysfunction.
- Lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese VAI (CVAI) are proposed surrogate indices for visceral adipose tissue.
- Prospective evidence linking these visceral obesity indices to diabetic retinopathy (DR) is limited.
Purpose Of The Study
- To investigate the longitudinal associations between LAP, VAI, and CVAI and the incidence of DR.
- To assess the risk of new-onset DR in Chinese patients with diabetes based on these visceral obesity markers.
Main Methods
- Prospective cohort study in Guangzhou, China, with 1403 diabetic patients without baseline DR.
- LAP, VAI, and CVAI calculated using sex-specific equations; DR assessed via fundus photography.
- Time-dependent Cox proportional hazard models and restricted cubic spline curves used to analyze associations and dose-response relationships.
Main Results
- A 1-SD increase in LAP, VAI, or CVAI was associated with significantly increased risk of new-onset DR.
- Hazard ratios for 1-SD increment were 1.24 for LAP, 1.22 for VAI, and 1.48 for CVAI.
- Nonlinear dose-response relationships were observed for LAP and VAI with incident DR.
Conclusions
- Visceral obesity, indicated by LAP, VAI, or CVAI, is independently associated with an elevated risk of new-onset DR in Chinese diabetic patients.
- Findings suggest incorporating regular monitoring of visceral obesity indices into clinical practice for DR prevention.
- These simple indices may serve as valuable tools for identifying individuals at higher risk for DR.
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