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Published on: September 8, 2013
Cross Dehydrogenative Coupling of SF4-Alkyne with Tetrahydroisoquinolines
Arvind Kumar Yadav1,2, Putri Nur Arina Mohd Ariff1, Koki Kawai1
1Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan.
Abstract:
This study introduces a dual-catalytic method for cross-dehydrogenative coupling (CDC) between tetrahydroisoquinolines and Py-SF4-alkyne using visible-light photoredox catalysis. This protocol enables selective C(sp3)-H alkynylation, expanding the synthetic toolkit for SF4-based molecules. Demonstrating efficiency and substrate versatility, this approach opens new avenues in hexacoordinated tetrafluorinated sulfur chemistry and CDC strategies and holds significant promise for drug discovery and materials science.
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