Related Experiment Video

Updated: Jul 4, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K

Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: implications for

Daniel Elías-López1,2,3, Takahito Doi1,2, Børge G Nordestgaard1,2,4

  • 1Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev Gentofte.

Current Opinion in Clinical Nutrition and Metabolic Care
|February 6, 2024
PubMed

Insights

Elevated remnant cholesterol and low-grade inflammation significantly increase atherosclerotic cardiovascular disease (ASCVD) risk. Their combined presence poses a particularly high risk, necessitating further research into targeted therapies for ASCVD prevention.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Lipid Metabolism

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality globally.
  • Residual ASCVD risk is partly explained by elevated remnant cholesterol and low-grade inflammation.
  • The combined effect of these factors on ASCVD risk is a growing area of concern.

Approach:

  • Review of recent observational and genetic Mendelian randomization studies.
  • Analysis of the independent and combined roles of remnant cholesterol and inflammation in ASCVD.
  • Evaluation of current evidence on the dual threat of high remnant cholesterol and low-grade inflammation.

Key Points:

  • Recent studies confirm a causal link between elevated remnant cholesterol, low-grade inflammation, and ASCVD risk.
  • The coexistence of high remnant cholesterol and low-grade inflammation amplifies ASCVD risk.
  • Observational data highlights this dual risk factor combination as particularly dangerous.

Conclusions:

  • Elevated remnant cholesterol and low-grade inflammation are critical contributors to ASCVD risk.
  • The synergistic effect of these factors warrants increased clinical attention.
  • Further research is needed to explore the efficacy of combined lipid-lowering and anti-inflammatory treatments for ASCVD.
Abstract

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

13.4K

Related Concept Videos

Inflammation01:38

Inflammation

Overview
53.4K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
164
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
548
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
741