The influence of social isolation on ethanol preference behavior and dopamine release in telencephalon slices in mice

We examined the relation between the duration of social isolation and alterations in ethanol preference behavior and the dopamine release in telencephalon slices in mice. Ethanol preference developed only after an isolation period of 2 weeks and a further ethanol treatment of 2 weeks. It did not appear after an isolation period of 6 weeks, in mice without ethanol treatment, and in group-housed mice. The dopamine release was lowered in mice isolated for 2 weeks and is normalized in combination with ethanol treatment. The dopamine release inhibition evoked by social isolation of 2 weeks probably reflects a functional state with high sensitivity for induction of an ethanol preference behaviour.