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[Circ_0026134 regulates the miR-1270/GRB2 pathway to affect the radiosensitivity of hepatoma cells]

X Y Zhao1, Y Y Liu1, L P Li1

  • 1Department of Comprehensive Intervention, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; Zhengzhou 450000, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|February 6, 2024
PubMed

Insights

Silencing circular RNA 0026134 (circ_0026134) enhances radiation therapy effectiveness in hepatoma cells. This occurs by downregulating the miR-1270/growth factor receptor-bound protein 2 (GRB2) pathway, improving radiosensitivity.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Context:

  • Hepatocellular carcinoma (HCC) exhibits increasing incidence and mortality worldwide.
  • Radiotherapy is a key treatment modality for HCC, but resistance remains a challenge.
  • Circular RNAs (circRNAs) are emerging as critical regulators in various cancers, including HCC.

Purpose:

  • To investigate the role of circ_0026134 in regulating the radiosensitivity of hepatoma cells.
  • To elucidate the molecular mechanism involving the miR-1270/GRB2 pathway.
  • To assess the therapeutic potential of targeting circ_0026134 in HCC.

Summary:

  • circ_0026134 and GRB2 expression were elevated, while miR-1270 was decreased in liver cancer tissues.
  • circ_0026134 directly targets miR-1270, and miR-1270 targets GRB2, forming a regulatory axis.
  • Silencing circ_0026134 or overexpressing miR-1270 significantly enhanced the anti-tumor effects of radiation, including reduced proliferation, migration, invasion, and increased apoptosis.
  • Knockdown of circ_0026134 inhibited tumor growth in vivo.

Impact:

  • This study identifies circ_0026134 as a novel regulator of radiosensitivity in hepatoma.
  • Targeting the circ_0026134/miR-1270/GRB2 pathway offers a potential strategy to overcome radioresistance in HCC.
  • Findings provide a basis for developing new therapeutic approaches to improve HCC treatment outcomes.
Keywords:
ApoptosisCell proliferationGrowth factor receptor binding protein 2Liver cancerMicro RNA1270Migration and invasionRadio-sensitivitycircular _0026134

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