Patient-reported outcome for physical function in idiopathic inflammatory myopathy

Area of Science:

• Rheumatology
• Patient-Reported Outcomes

Background:

• Idiopathic inflammatory myopathies (IIM) require validated patient-reported outcome measures (PROMs).
• The National Institutes of Health's Patient-Reported Outcomes Measurement Information System (PROMIS) physical function-20 (PF-20) is a potential PROM for IIM.

Purpose of the Study:

• To assess the feasibility, compliance, and psychometric properties of the PROMIS PF-20 in a large US IIM population.
• To compare PROMIS PF-20 performance between traditional clinic-based and remote tele-research cohorts.

Main Methods:

• The 'Myositis Patient Centered Tele-Research' (My PACER) study enrolled 120 IIM patients.
• Patients were recruited via traditional clinic visits (centre-based cohort, CBC) or remotely (tele-research cohort, TRC).
• PROMIS PF-20 data were collected monthly for 6 months, alongside other patient and clinician-reported outcomes.

Main Results:

• PROMIS PF-20 showed no association with age, sex, or race.
• Compliance and completion rates were similar between TRC and CBC.
• PROMIS PF-20 demonstrated strong reliability, validity, and responsiveness, correlating with core myositis measures.

Conclusions:

• PROMIS PF-20 exhibits favorable psychometric properties for use in myositis patients.
• The measure shows similar adherence regardless of local or remote enrollment, supporting its use in diverse research settings.