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Association and Interacting Factors between Bronchial Asthma and Attention-deficit Hyperactivity Disorder in
1Department of Paediatrics, Taizhou Municipal Hospital, 318000 Taizhou, Zhejiang, China.
Insights
Children with attention-deficit hyperactivity disorder (ADHD) have a significantly higher likelihood of developing bronchial asthma. This meta-analysis highlights a strong association, suggesting a need for integrated management strategies for both conditions.
Area of Science:
- Pediatric Health
- Neurodevelopmental Disorders
- Respiratory Medicine
Background:
- Investigating the potential association between bronchial asthma and attention-deficit hyperactivity disorder (ADHD) in pediatric populations.
- Addressing the need for a systematic evaluation of existing evidence on the comorbidity of asthma and ADHD.
Approach:
- Conducted a comprehensive systematic review and meta-analysis of studies published up to September 28, 2023.
- Searched multiple databases including PubMed, Web of Science, ScienceDirect, CNKI, Wanfang, and CBM.
- Synthesized data from 10 articles involving 729,375 participants using statistical analyses and odds ratios (ORs) with 95% confidence intervals (CIs).
Key Points:
- A statistically significant association was found between ADHD and an increased likelihood of bronchial asthma (OR = 1.46, 95% CI: 1.41–1.51, p < 0.001).
- Identified multiple potential contributing factors, including genetics, immune function, comorbidities, and environmental influences.
- The analysis revealed significant heterogeneity (I2 = 58%), indicating variability across studies.
Conclusions:
- This meta-analysis provides robust evidence for a significant link between bronchial asthma and ADHD in children.
- Children with ADHD exhibit a greater prevalence of bronchial asthma.
- Further research is warranted to elucidate the complex interplay of factors contributing to this association, informing clinical practice for integrated care.
Background:
This study aims to systematically assess the possible link between bronchial asthma usage and attention-deficit hyperactivity disorder (ADHD) in children.
Methods:
PubMed, Web of Science, ScienceDirect, CNKI, Wanfang, and the China Biological Medicine Database (CBM) were searched for relevant articles published from database inception until September 28, 2023. The statistical analyses were conducted using Stata 15.1 software, followed by a quantitative meta-analysis to synthesize the results of the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).
Results:
A total of 10 articles involving 729,375 participants were included in the meta-analysis. The overall analysis revealed a statistically significant association between ADHD and an increased likelihood of having bronchial asthma, as indicated by a pooled odds ratio (OR) of 1.46 and a 95% confidence interval (CI) ranging from 1.41 to 1.51, p < 0.001, I2 = 58%. Potential associated factors linking bronchial asthma and ADHD in children include demographic characteristics, healthcare access, socioeconomic factors, comorbidities, genetic susceptibility, immune dysregulation, chronic conditions, growth and development factors, and parental/environmental influences.
Conclusion:
This systematic review and meta-analysis presents convincing evidence for a notable link between bronchial asthma and ADHD in children. The results indicate an increased likelihood of bronchial asthma among children with ADHD compared to those without the condition. Additionally, various potential factors can underlie the association between bronchial asthma and ADHD in children, necessitating further research to fully comprehend their complex relationship. These findings have implications for clinical practice, highlighting the need for an integrated approach in managing asthma and ADHD.
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