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Coagulation Testing in Real-World Setting: Insights From a Comprehensive Survey.
Hae In Bang1, Ja Young Lee2, Hyun-Young Kim3
1Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, The Republic of Korea.
Summary
This survey reveals that while common coagulation tests like prothrombin time (PT) and activated partial thromboplastin time (aPTT) are widely available in Korean labs, specialized tests like lupus anticoagulant (LA) assays need standardization. Continuous education and quality control are recommended.
Area of Science:
- Clinical Laboratory Science
- Hematology
- Diagnostic Testing
Background:
- Coagulation testing is crucial for diagnosing and managing bleeding and thrombotic disorders.
- Real-world data on the current practices and availability of coagulation tests in clinical laboratories are essential for quality improvement.
Purpose of the Study:
- To assess the availability and practices of various coagulation laboratory tests in Korea.
- To identify variations in analytic and postanalytic steps for key hemostasis and thrombosis tests.
Main Methods:
- A 65-question survey was distributed to Korean clinical laboratories between July and September 2022.
- The survey focused on practices for prothrombin time (PT), activated partial thromboplastin time (aPTT), plasma-mixing studies, lupus anticoagulant (LA) tests, platelet function tests, and coagulation factor assays.
- A response rate of 77.9% (81/104 institutions) was achieved.
Main Results:
- Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were performed in all surveyed institutions.
- D-dimer and fibrinogen tests were the next most frequent, followed by platelet function and plasma-mixing studies.
- Significant variations were observed in the performance of mixing tests and LA assessments, with practices differing based on hospital size.
Conclusions:
- While most Korean laboratories adhere to international guidelines for coagulation testing, specific tests like mixing studies and LA assays require further standardization.
- Enhancing the performance of coagulation testing necessitates continuous education on test methodologies and robust internal and external quality control measures.
