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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Disulfidptosis: Six Riddles Necessitating Solutions.

Xinyu Wang1, Chanjuan Zheng1, Hui Yao1,2

  • 1Key Laboratory of Translational Cancer Stem Cell Research, Department of Pathophysiology, Hunan Normal University School of Medicine, Changsha, Hunan 410013, China.

International Journal of Biological Sciences
|February 7, 2024
PubMed
Summary

Disulfidptosis is a cell death pathway triggered by cystine buildup and disulfide stress, impacting the actin cytoskeleton. Understanding this process is key to new therapeutic strategies.

Keywords:
Actin cytoskeletonCellular metabolismDisulfide stressDisulfidptosisProgrammed cell death

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Metabolic Pathways

Background:

  • Disulfidptosis results from intracellular cystine accumulation and disulfide stress.
  • This stress affects actin cytoskeleton proteins due to reduced NADPH from the pentose phosphate pathway.
  • High expression of SLC7A11 is linked to this cell death mechanism.

Discussion:

  • Disulfidptosis is a form of cell death caused by redox imbalance.
  • It arises from disrupted amino acid and glucose metabolism.
  • The discovery has generated significant interest but requires further investigation.

Key Insights:

  • Disulfidptosis links metabolic disruption to programmed cell death.
  • It highlights the role of redox balance in cellular integrity.
  • SLC7A11 and NADPH levels are critical factors.

Outlook:

  • Further research is needed to fully elucidate disulfidptosis mechanisms.
  • Understanding its pathophysiological relevance is crucial.
  • Disulfidptosis presents a potential therapeutic target for various conditions.