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Marginal zone lymphoma with severe rashes: A case report
Si-Jun Bai1, Ye Geng1, Yi-Nan Gao1
1Department of Hematology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China.
Background:
Marginal zone lymphoma (MZL) is an indolent subtype of non-Hodgkin lymphoma (NHL), which is rare clinically with severe rashes as the initial symptom.
Case Summary:
This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge. First-line treatment with rituximab combined with zanubrutinib had poor effects. However, after switching to obinutuzumab combined with zanubrutinib, the case was alleviated, and the rashes disappeared.
Conclusion:
For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody (mAb) combination therapy, switching to a type II anti-CD20 mAb combination regimen may be considered. This approach may provide a new perspective in the treatment of MZL.
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