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[The Dynamic Model of the Active-Inactive Cell Interface].

Deqing Zhang1, Haoshun Zhang1, Bo Li1

  • 1（ 100084） Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|February 7, 2024
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Summary

Active-inactive cell interfaces exhibit three distinct morphologies: flat, wavy, and finger-like. Cell orientation and topological defects at these interfaces dictate their morphodynamics and resulting structures.

Keywords:
ActivityCell interfaceTopological defect

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Area of Science:

  • Condensed matter physics
  • Biophysics
  • Materials science

Context:

  • Cell monolayers exhibit complex behaviors at their interfaces.
  • Active liquid crystal theory provides a framework for understanding active matter dynamics.
  • Understanding active-inactive cell interfaces is crucial for tissue engineering and developmental biology.

Purpose:

  • To investigate the morphodynamics of active-inactive cell monolayer interfaces.
  • To model and simulate interface behavior using active liquid crystal theory.
  • To correlate interface morphology with cell orientation and topological defects.

Summary:

  • A continuum mechanical model based on active liquid crystal theory was developed.
  • Numerical simulations using finite difference and lattice Boltzmann methods were employed.
  • Three interface morphologies (flat, wavy, finger-like) were identified, each associated with specific cell orientations, topological defects (-1/2, neutral, +1/2), and interface charges (negative, neutral, positive).

Impact:

  • Cell alignment at interfaces significantly influences their morphology.
  • The dynamics of topological defects are intrinsically linked to interface shape.
  • This research offers insights into self-organization principles in active matter systems.