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The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1

Jing Xiao1,2, Liqun Wang2, Yuan Zhuang2

  • 1Department of Reproductive Medicine Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University Nanchang 330006, Jiangxi, PR China.

American Journal of Translational Research
|February 7, 2024
PubMed
Abstract

Insights

Otubain2 (OTUB2) promotes cervical cancer (CC) progression by stabilizing Forkhead box M1 (FOXM1). This deubiquitinase enzyme is overexpressed in CC and linked to poor patient outcomes, highlighting its oncogenic role.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Otubain2 (OTUB2), a deubiquitinase, plays roles in various cellular processes.
  • The involvement of OTUB2 in cervical cancer (CC) pathogenesis remains unexplored.

Purpose of the Study:

  • To investigate the role and mechanism of OTUB2 in cervical cancer (CC).
  • To determine if OTUB2 acts as an oncogene in CC progression.

Main Methods:

  • Analysis of OTUB2 expression in CC patient data (TCGA) and patient tissues.
  • In vitro and in vivo experiments to assess OTUB2's oncogenic function.
  • Quantitative proteomics to identify OTUB2 targets, focusing on Forkhead box M1 (FOXM1).

Main Results:

  • OTUB2 is overexpressed in CC tissues and correlates with poor prognosis.
  • OTUB2 knockdown inhibits CC cell growth, while its upregulation promotes proliferation.
  • OTUB2 deubiquitinates and stabilizes FOXM1, a key driver of OTUB2-mediated CC cell growth.

Conclusions:

  • OTUB2 promotes cervical cancer progression.
  • The mechanism involves OTUB2-mediated deubiquitination and stabilization of FOXM1.
Keywords:
FOXM1OTUB2cell proliferationcervical cancer

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