Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Area of Science:

• Molecular Biology
• Cardiovascular Disease Research
• Biomarker Discovery

Background:

• Cleavage factor Im25 (CFIm25) influences mRNA editing and cellular functions, implicated in various diseases.
• Peripheral blood monocytes are recognized for their diagnostic and prognostic roles in coronary atherosclerosis.
• The predictive potential of CFIm25 in monocytes for coronary atherosclerosis remains unexplored.

Purpose of the Study:

• To investigate the association between CFIm25 expression in peripheral blood monocytes and the severity of coronary atherosclerosis.
• To determine if CFIm25 serves as a predictive biomarker for coronary artery lesions.

Main Methods:

• Collected coronary angiography data and Gensini scores from 267 patients to quantify coronary atherosclerosis.
• Isolated peripheral blood monocytes and measured CFIm25 RNA expression.
• Utilized univariate and multivariate logistic regression and ROC curve analysis to assess predictive value.

Main Results:

• CFIm25 expression showed a negative correlation with Gensini scores and the number of affected coronary vessels.
• Lower CFIm25 expression was identified as a protective factor against severe coronary lesions, ≥50% stenosis, and three-vessel disease.
• Receiver operating characteristic (ROC) curves demonstrated significant predictive capabilities for CFIm25 in identifying various degrees of coronary atherosclerosis.

Conclusions:

• CFIm25 expression in monocytes is inversely related to the degree of coronary atherosclerosis.
• CFIm25 expression is a valuable predictor for the severity and extent of coronary artery lesions.