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Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis
Meng Liu1, Xiaoxiao Chen1, Zhan Gu1
1Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
Insights
Lower cleavage factor Im25 (CFIm25) expression in monocytes predicts coronary atherosclerosis severity. This finding suggests CFIm25 may serve as a biomarker for coronary artery disease progression.
Area of Science:
- Molecular Biology
- Cardiovascular Disease Research
- Biomarker Discovery
Background:
- Cleavage factor Im25 (CFIm25) influences mRNA editing and cellular functions, implicated in various diseases.
- Peripheral blood monocytes are recognized for their diagnostic and prognostic roles in coronary atherosclerosis.
- The predictive potential of CFIm25 in monocytes for coronary atherosclerosis remains unexplored.
Purpose of the Study:
- To investigate the association between CFIm25 expression in peripheral blood monocytes and the severity of coronary atherosclerosis.
- To determine if CFIm25 serves as a predictive biomarker for coronary artery lesions.
Main Methods:
- Collected coronary angiography data and Gensini scores from 267 patients to quantify coronary atherosclerosis.
- Isolated peripheral blood monocytes and measured CFIm25 RNA expression.
- Utilized univariate and multivariate logistic regression and ROC curve analysis to assess predictive value.
Main Results:
- CFIm25 expression showed a negative correlation with Gensini scores and the number of affected coronary vessels.
- Lower CFIm25 expression was identified as a protective factor against severe coronary lesions, ≥50% stenosis, and three-vessel disease.
- Receiver operating characteristic (ROC) curves demonstrated significant predictive capabilities for CFIm25 in identifying various degrees of coronary atherosclerosis.
Conclusions:
- CFIm25 expression in monocytes is inversely related to the degree of coronary atherosclerosis.
- CFIm25 expression is a valuable predictor for the severity and extent of coronary artery lesions.
Abstract:
Background: Cleavage factor Im25 (CFIm25) regulates cell function by affecting mRNA editing processes and plays diverse roles in various diseases. Studies have found that peripheral blood monocytes are valuable in diagnosing and prognosing coronary atherosclerosis. However, no studies have examined the predictive value of CFIm25 expression in peripheral blood monocytes for coronary atherosclerosis. Methods and Results: We collected the coronary angiography results of 267 patients and calculated the Gensini score to evaluate their degree of coronary atherosclerosis. We isolated peripheral blood monocytes and detected CFIm25 RNA expression. Based on their Gensini score, we divided the patients into negative (0, n = 46), mild lesion (≤ 8, n = 71), moderate lesion (8-23, n = 76), and severe lesion (≥ 23, n = 74) groups. Results showed that CFIm25 expression correlated negatively with the Gensini score and the number of involved coronary vessels. Univariate and multivariate binary logistic regression analyses showed that CFIm25 expression in peripheral blood monocytes was a protective factor for severe lesions, ≥ 50% stenosis, and three-vessel lesions. The areas under the receiver operating characteristic curve of CFIm25 expression for predicting lesions, severe lesions, ≥50% stenosis, and three-vessel lesions were 0.743, 0.735, 0.791, and 0.736, respectively. Conclusions: CFIm25 expression in peripheral blood monocytes correlates negatively with the degree of coronary atherosclerosis and helps predict the severity and number of coronary artery lesions.
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