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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
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Microbial Profile, Antimicrobial Susceptibility, and Prevalence of MDR/XDR Pathogens Causing Medical Device
Vaibhav R Suryawanshi1, Atmaram Pawar2, Bharat Purandare3
1Department of Pharmacy Practice, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, BVDU Katraj Campus, Pune, Maharashtra, India.
Summary
This study identified common multi-drug resistant pathogens in medical device-associated infections (MDAIs). It highlights the need for better antimicrobial stewardship to combat resistant bacteria like carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii.
Area of Science:
- Infectious Diseases
- Microbiology
- Critical Care Medicine
Background:
- Medical device-associated infections (MDAIs) pose a significant challenge in healthcare settings.
- Limited data exists on the microbial landscape and antimicrobial resistance patterns of pathogens causing MDAIs.
- This study addresses the scarcity of research on MDAIs in tertiary care settings.
Purpose of the Study:
- To investigate the microbial profile of MDAIs.
- To determine antimicrobial susceptibility patterns of isolated pathogens.
- To ascertain the prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) pathogens causing MDAIs.
Main Methods:
- An ambispective, observational, surveillance-based study was conducted over two years.
- The study focused on intensive care unit (ICU) and high dependency unit (HDU) patients.
- Central-line-associated bloodstream infections (CLABSI), catheter-associated urinary tract infections (CAUTI), and ventilator-associated pneumonia (VAP) were analyzed.
Main Results:
- A total of 104 pathogens were isolated from 90 patients.
- Common MDR gram-positive pathogens included Staphylococcus epidermidis (CoNS) and Staphylococcus capitis.
- Carbapenem-resistant Klebsiella pneumoniae, Stenotrophomonas maltophilia, and Acinetobacter baumannii were prevalent MDR gram-negative pathogens.
- Extensively drug-resistant (XDR) K. pneumoniae and S. maltophilia were identified.
- Candida parapsilosis was the most common fungal pathogen in CLABSI and CAUTI.
Conclusions:
- The study identified key MDR/XDR pathogens contributing to MDAIs in ICU/HDU settings.
- Findings underscore the urgent need for enhanced antimicrobial stewardship programs.
- Surveillance of microbial profiles and resistance patterns is crucial for effective infection control.
