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Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury: Current Understanding and Therapeutic Options

Prashant Nasa1, Nimisha A Majeed2, Deven Juneja3

  • 1Department of Critical Care Medicine, NMC Specialty Hospital; Department of Internal Medicine, College of Medicine and Health Sciences, Abu Dhabi, United Arab Emirates.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|February 7, 2024
PubMed

Keywords:
Acute brain injuryAutonomic dysfunctionAutonomic instabilityAutonomic stormBrain injuries traumaticParoxysmal sympathetic hyperactivity

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The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
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