Clinicopathological and survival analysis of primary spindle cell carcinoma of the breast in Chinese patients

Area of Science:

• Oncology
• Pathology

Background:

• Spindle cell carcinoma (SpCC) of the breast is rare, limiting understanding of its characteristics.
• Limited data exists on SpCC in Chinese populations.

Purpose of the Study:

• To analyze clinicopathological features of breast SpCC in Chinese patients.
• To evaluate survival outcomes and prognostic factors for breast SpCC.

Main Methods:

• Retrospective analysis of 160 breast SpCC cases (23 from author's center, 137 from literature).
• Data collected from 2004-2021, including clinical, pathological, and survival information.
• Literature search conducted on Chinese databases and PubMed.

Main Results:

• Median age was 52; 84.8% diagnosed at early stages (I/II).
• Low axillary lymph node involvement (15.0%); majority HR-HER2- (85.4%).
• High recurrence rate (46.0%) with lung metastasis common; 3-year DFS 55.9%, 3-year OS 67.0%. T stage independently predicted OS.

Conclusions:

• Breast SpCC often presents early but has a poor prognosis.
• T stage is a significant prognostic factor for overall survival.
• Further research is needed to develop better treatments to improve outcomes and prevent recurrence.