Recent advances of Pin1 inhibitors as potential anticancer agents

Area of Science:

• Biochemistry
• Molecular Biology
• Oncology

Background:

• Pin1 (proline isomerase peptidyl-prolyl isomerase NIMA-interacting-1) is a PPIase enzyme.
• It regulates critical cellular processes including proliferation, division, and apoptosis.
• Pin1 overexpression is linked to cancer initiation, progression, and metastasis.

Purpose of the Study:

• To comprehensively summarize known Pin1 inhibitors.
• To highlight their structures, biological functions, and binding modes.
• To provide a reference for future Pin1 inhibitor drug discovery in cancer treatment.

Main Methods:

• Literature review of reported Pin1 inhibitors.
• Analysis of inhibitor structures and their corresponding biological activities.
• Examination of documented binding modes of Pin1 inhibitors.

Main Results:

• Overview of diverse Pin1 inhibitor structures.
• Correlation between Pin1 inhibition and reduced tumor growth, metastasis, and enhanced chemosensitivity.
• Detailed analysis of specific inhibitor binding interactions.

Conclusions:

• Pin1 inhibitors demonstrate significant therapeutic potential in various cancers.
• Targeting Pin1 is a promising strategy for cancer therapy.
• This review serves as a valuable resource for developing novel Pin1-targeted cancer drugs.