Deep learning-based algorithms for low-dose CT imaging: A review

The computed tomography (CT) technique is extensively employed as an imaging modality in clinical settings. The radiation dose of CT, however, is significantly high, thereby raising concerns regarding the potential radiation damage it may cause. The reduction of X-ray exposure dose in CT scanning may result in a significant decline in imaging quality, thereby elevating the risk of missed diagnosis and misdiagnosis. The reduction of CT radiation dose and acquisition of high-quality images to meet clinical diagnostic requirements have always been a critical research focus and challenge in the field of CT. Over the years, scholars have conducted extensive research on enhancing low-dose CT (LDCT) imaging algorithms, among which deep learning-based algorithms have demonstrated superior performance. In this review, we initially introduced the conventional algorithms for CT image reconstruction along with their respective advantages and disadvantages. Subsequently, we provided a detailed description of four aspects concerning the application of deep neural networks in LDCT imaging process: preprocessing in the projection domain, post-processing in the image domain, dual-domain processing imaging, and direct deep learning-based reconstruction (DLR). Furthermore, an analysis was conducted to evaluate the merits and demerits of each method. The commercial and clinical applications of the LDCT-DLR algorithm were also presented in an overview. Finally, we summarized the existing issues pertaining to LDCT-DLR and concluded the paper while outlining prospective trends for algorithmic advancement.