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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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  1. Home
  3. Homocysteine Serum Levels In Patients With Ruptured And Unruptured Intracranial Aneurysms: A Case-control Study.
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  3. Homocysteine Serum Levels In Patients With Ruptured And Unruptured Intracranial Aneurysms: A Case-control Study.

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Homocysteine serum levels in patients with ruptured and unruptured intracranial aneurysms: a case-control study.

João Paulo Mota Telles1, Jefferson Rosi Junior2, Vitor Nagai Yamaki2

  • 1Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.

Arquivos De Neuro-Psiquiatria
|February 7, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study found no significant difference in homocysteine levels between patients with ruptured and unruptured intracranial aneurysms. Elevated homocysteine did not correlate with vasospasm or poorer functional outcomes in ruptured aneurysm cases.

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Area of Science:

  • Neurology
  • Vascular Biology
  • Biochemistry

Background:

  • Limited data exists on homocysteine's role in intracranial aneurysm formation and rupture.
  • Understanding factors influencing aneurysm rupture is crucial for patient outcomes.

Purpose of the Study:

  • To compare homocysteine levels in patients with ruptured versus unruptured intracranial aneurysms.
  • To investigate the association between homocysteine levels, vasospasm, and functional outcomes in ruptured aneurysm patients.

Main Methods:

  • Retrospective case-control study design.
  • Inclusion of 348 participants: 114 with ruptured and 234 with unruptured aneurysms.
  • Logistic regression analysis to assess associations.

Main Results:

  • No significant difference in median homocysteine levels between ruptured (10.75µmol/L) and unruptured (11.5µmol/L) aneurysm groups.
  • No significant association found between homocysteine levels and aneurysm rupture status.
  • Homocysteine levels did not correlate with vasospasm or excellent functional outcomes at 6 months post-rupture.

Conclusions:

  • Homocysteinemia does not appear to be a differentiating factor between ruptured and unruptured intracranial aneurysms.
  • Homocysteine levels are not associated with vasospasm or functional recovery in patients with ruptured intracranial aneurysms.