Related Experiment Video

Updated: Jul 15, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.4K

Impact of Age on the Relationship between Cross-Clamp Time and Mortality in Cardiac Surgery

Murat Mukharyamov1, Hristo Kirov1, Tulio Caldonazo1

  • 1Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany.

The Thoracic and Cardiovascular Surgeon
|February 7, 2024
PubMed

Insights

Age significantly increases mortality risk, especially when combined with longer aortic cross-clamp times during surgery. This age-associated risk factor warrants careful consideration in surgical patient management.

Area of Science:

  • Cardiovascular Surgery
  • Geriatric Medicine
  • Clinical Risk Factor Analysis

Background:

  • Age is a known independent risk factor for mortality.
  • Existing comorbidities do not fully explain age-associated mortality risk.
  • Additional contributing factors to age-related surgical outcomes require investigation.

Purpose of the Study:

  • To investigate the independent contributions of age and aortic cross-clamp time to mortality.
  • To determine how age modifies the impact of cross-clamp time on mortality risk.
  • To identify key factors influencing surgical outcomes in elderly patients.

Main Methods:

  • Systematic literature search of 161 manuscripts.
  • Meta-analysis of 32 studies including 18,256 patients.
  • Statistical analysis of age and aortic cross-clamp time as independent risk factors for mortality.

Main Results:

  • Both age and aortic cross-clamp time were significant independent predictors of mortality.
  • Mortality risk increased substantially with longer cross-clamp times.
  • The detrimental effect of cross-clamp time on mortality was significantly amplified in older patients.

Conclusions:

  • Age significantly accelerates the increase in mortality risk associated with prolonged aortic cross-clamp times.
  • This interaction highlights the heightened vulnerability of older patients to surgical stress.
  • Optimizing cross-clamp duration is crucial for improving outcomes in elderly surgical populations.

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

8.0K
Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

3.4K

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...