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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
Yifei Tan1,2, Yongjie Zhou1, Wei Zhang3
1Department of Liver Transplantation Center and Laboratory of Liver Transplantation, West China Hospital of Sichuan University, Chengdu, China.
Cellular Oncology (Dordrecht, Netherlands)
|February 7, 2024
Summary
Repaglinide (RPG) targets the FOXO3/lumican/p53 pathway, inhibiting hepatocellular carcinoma (HCC) progression. This study reveals lumican
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Aberrant N-linked glycoproteins are implicated in various cancers.
- Understanding their role in hepatocellular carcinoma (HCC) is crucial for therapeutic strategies.
Purpose of the Study:
- To explore aberrantly expressed glycoproteins in HCC.
- To investigate their role in HCC progression and identify potential therapeutic targets.
Main Methods:
- Mass spectrometry and immunohistochemistry (IHC) identified glycoproteins.
- In vitro and in vivo assays assessed lumican's role in HCC.
- Chromatin immunoprecipitation (ChIP) and luciferase assays identified transcription factors.
- Repaglinide (RPG) effects on the FOXO3/lumican/p53 axis were evaluated.
Main Results:
- Lumican was upregulated in HCC, correlating with poor prognosis.
- Lumican knockdown inhibited HCC growth by affecting the p53/p21 pathway.
- FOXO3 was identified as a transcription factor for lumican.
- RPG inhibited HCC progression by disrupting the FOXO3/lumican/p53 axis.
Conclusions:
- Repaglinide (RPG) prevents HCC development and progression.
- The FOXO3/lumican/p53 axis is a key pathway targeted by RPG in HCC.
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