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Related Experiment Videos

NOR variability in twins.

R Weltens, M Kirsch-Volders, L Hens

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Genetic factors significantly determine nucleolar organizing region (NOR) patterns, especially when controlling for chromosome types. However, non-genetic influences also play a role, even in identical twins.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Cell Biology

    Background:

    • Nucleolar organizing regions (NORs) are crucial for ribosome biogenesis.
    • AgNOR staining quantifies NORs, reflecting cellular activity.
    • Understanding the heritability of NOR patterns is key to genetic studies.

    Purpose of the Study:

    • To investigate the genetic determination of AgNOR (NOR+) and AgNOR amount (NORM+) patterns.
    • To assess the influence of zygosity and specific chromosome types (D and G) on NOR expression.
    • To differentiate between genetic and non-genetic factors affecting NOR patterns.

    Main Methods:

    • Analysis of 12 twin pairs (3 female MZ, 4 male MZ, 5 male DZ).
    • Multilevel analyses of variance (ANOVA) were employed.

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  • Controlled for zygosity, chromosome types D and G, and their interaction.

    • Main Results:

    • Within-pair variance for NOR+ and NORM+ was significantly greater in dizygotic (DZ) than monozygotic (MZ) twins when chromosome types D and G were controlled.
    • Genetic factors strongly influence NOR+ and NORM+ patterns, particularly when accounting for chromosome types.
    • Non-genetic factors also impact Ag-NOR patterns, with approximately 50% of cells showing rDNA transcription independent of the rDNA background, leading to intrapair differences in MZ twins.

    Conclusions:

    • AgNOR patterns are significantly genetically determined, especially when considering specific chromosome types.
    • While genetic factors are dominant, non-genetic influences contribute to variations in Ag-NOR expression.
    • Further research is needed to fully elucidate the interplay between genetic and environmental factors in rDNA transcription patterns.