Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K
Protein Complex Assembly02:41

Protein Complex Assembly

10.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.6K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

19.8K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
19.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gold Nanoparticles-Modified 2D Self-Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency.

Macromolecular rapid communications·2024
Same author

Ti<sub>3</sub>C<sub>2</sub> Nanosheets Functionalized with Ferritin-Biomimetic Platinum Nanoparticles for Electrochemical Biosensors of Nitrite.

Biosensors·2024
Same author

Injectable Chitosan Hydrogels Doped with 2D Peptide Nanosheet-Drug Conjugates for Glutathione-Responsive Sustained Drug Delivery.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

Assembling Ag<sub>2</sub>S quantum dots onto peptide nanosheet as a biomimetic two-dimensional nanoplatform for synergistic near infrared-II fluorescent imaging and photothermal therapy of tumor.

Journal of colloid and interface science·2024
Same author

Fabrication and Functional Regulation of Biomimetic Interfaces and Their Antifouling and Antibacterial Applications: A Review.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same author

Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications.

Journal of nanobiotechnology·2023

Related Experiment Video

Updated: Jul 4, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.4K

Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications.

Rongqiu Mu1, Danzhu Zhu1, Sama Abdulmalik2

  • 1College of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, China.

Bioactive Materials
|February 8, 2024
PubMed
Summary

Peptide nanomaterials offer versatile biomaterial solutions for tissue engineering and biomedicine due to their design flexibility and self-assembly properties. This review highlights advances in stimuli-responsive peptide nanomaterials for targeted drug delivery and therapeutic applications.

Keywords:
Biomedical applicationsFunctional modulationMolecular designPeptide assembliesStimuli-responsive nanomaterials

More Related Videos

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Related Experiment Videos

Last Updated: Jul 4, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.4K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

12.9K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Biology

Background:

  • Peptide molecules possess inherent advantages like design flexibility, self-assembly, biocompatibility, and biodegradability, making them ideal for biomedical applications.
  • Functionalizing self-assembled peptide nanomaterials with additive components enhances their stimuli-responsive capabilities for precise applications.
  • The integration of peptides into advanced nanomaterials is crucial for developing next-generation therapeutics and biomedical devices.

Purpose of the Study:

  • To review recent advancements in peptide molecular design, self-assembly, and functional tailoring of peptide-based nanomaterials.
  • To analyze strategies for synthesizing single, dual, and multiple stimuli-responsive peptide nanomaterials with diverse dimensions.
  • To discuss the functional regulation of peptide nanomaterials incorporating active components like metal oxides, DNA/RNA, and 2D materials.

Main Methods:

  • Reviewing literature on peptide molecular design and self-assembly principles.
  • Analyzing synthesis strategies for stimuli-responsive peptide-based nanomaterials.
  • Discussing functionalization techniques using various active components (metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials).

Main Results:

  • Peptide nanomaterials can be designed for single, dual, or multiple stimuli-responsiveness (temperature, pH, ion, light, enzyme, ROS).
  • Functionalized peptide nanomaterials demonstrate potential in drug delivery, bioimaging, cancer therapy, gene therapy, and antibacterial applications.
  • Integration of diverse active components allows for tailored and enhanced functionality of peptide nanomaterials.

Conclusions:

  • Peptide-based nanomaterials represent a promising platform for advanced biomedical applications due to their tunable properties.
  • The review provides methodologies and techniques for synthesizing functional peptide nanomaterials, guiding future molecular-level design.
  • Further research into stimuli-responsive peptide nanomaterials will drive innovation in targeted therapies and regenerative medicine.