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Heparan sulfate modified proteins affect cellular processes central to neurodegeneration and modulate presenilin

Nicholas Schultheis, Alyssa Connell, Alexander Kapral

    Biorxiv : the Preprint Server for Biology
    |February 8, 2024
    PubMed
    Summary

    Heparan sulfate proteoglycans (HSPGs) are implicated in Alzheimer's disease (AD) pathogenesis. Modulating HSPG synthesis impacts pathways like autophagy and lipid metabolism, offering potential therapeutic targets for AD.

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