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Updated: Jul 4, 2025

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MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Taylor E Lange, Ali Naji, Ransome van der Hoeven

    Biorxiv : the Preprint Server for Biology
    |February 8, 2024
    PubMed
    Summary

    Myotubularin-related proteins (MTMR) regulate KRAS protein localization by maintaining plasma membrane phosphatidylserine (PtdSer) levels. Silencing MTMR disrupts this process, impacting cancer cell proliferation and differentiation.

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