Co-expression patterns of cancer associated fibroblast markers reveal distinct subgroups related to patient survival in oropharyngeal squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Cancer-associated fibroblast (CAF) markers in oropharyngeal squamous cell carcinoma (OPSCC) correlate with CD8 T-cell infiltration. Specific CAF marker combinations, like low PDGFRb, periostin, and α-SMA, predict improved patient survival.
Area Of Science
- Oncology
- Immunology
- Cancer Biology
Background
- Oropharyngeal squamous cell carcinoma (OPSCC) incidence is rising, linked to high-risk human papillomavirus (HPV).
- The tumor microenvironment significantly influences OPSCC progression and treatment response.
- Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment.
Purpose Of The Study
- To analyze the co-expression of four established CAF markers in OPSCC.
- To investigate the association between CAF markers and intratumoral CD8 T-cell infiltration.
- To determine the prognostic value of CAF markers in relation to patient survival and tumor characteristics.
Main Methods
- Digital analysis of immunohistochemical staining for FAP, PDGFRb, periostin, α-SMA, and CD8 in 216 OPSCC patients.
- Assessment of associations between CAF marker expression, CD8 T-cell infiltration, and clinical outcomes.
- Statistical analysis to identify independent predictors of survival.
Main Results
- Co-expression of CAF markers was common but not HPV-dependent.
- High FAP and PDGFRb expression correlated with increased CD8 T-cell infiltration.
- Low PDGFRb expression improved survival in female patients; a triple low (PDGFRb, periostin, α-SMA) phenotype independently predicted better survival.
Conclusions
- CAF marker expression patterns are linked to T-cell infiltration and patient survival in OPSCC.
- Specific CAF subgroups may serve as prognostic biomarkers.
- Further research into CAF heterogeneity could inform personalized OPSCC therapies.
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