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Primary Hepatic EBV-DLBCL Lymphoma in the Setting of COVID-19 Infection
Luisa Maria De Souza1, Mohamed Ismail1, Menna-Allah Elaskandrany2
1Department of Internal Medicine, Rutgers New Jersey Medical School University Hospital, Newark, NJ.
ACG Case Reports Journal
|February 8, 2024
Summary
This case study details a rare primary hepatic diffuse large B cell lymphoma (DLBCL) in a patient with a history of prolonged coronavirus disease 2019 (COVID-19). It highlights the potential link between COVID-19 and solid tumor development, urging further investigation.
Area of Science:
- Oncology
- Virology
- Hepatology
Background:
- Diffuse large B cell lymphoma (DLBCL) is a type of non-Hodgkin lymphoma.
- Primary hepatic DLBCL, originating in the liver, is exceptionally rare.
- Recent research explores potential links between viral infections and cancer development.
Observation:
- A 53-year-old male presented with fatigue and weight loss.
- Diagnostic workup revealed elevated liver enzymes and multiple low-density liver lesions.
- The patient had a history of prolonged coronavirus disease 2019 (COVID-19) four months prior to symptom onset.
Findings:
- Liver biopsy with immunohistochemical analysis confirmed primary hepatic diffuse large B cell lymphoma (DLBCL).
- This case represents a rare instance of DLBCL presenting solely within the liver.
- The temporal association suggests a possible, though unconfirmed, role of COVID-19 in DLBCL development.
Implications:
- This case underscores the importance of considering COVID-19 as a potential factor in the emergence of solid tumors.
- Further research is crucial to elucidate the relationship between COVID-19 and oncogenesis.
- Increased awareness and documentation of such cases are vital for understanding long-term health consequences of COVID-19.
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