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Primary Hepatic EBV-DLBCL Lymphoma in the Setting of COVID-19 Infection

Luisa Maria De Souza1, Mohamed Ismail1, Menna-Allah Elaskandrany2

  • 1Department of Internal Medicine, Rutgers New Jersey Medical School University Hospital, Newark, NJ.

ACG Case Reports Journal
|February 8, 2024
PubMed

Insights

This case study details a rare primary hepatic diffuse large B cell lymphoma (DLBCL) in a patient with a history of prolonged coronavirus disease 2019 (COVID-19). It highlights the potential link between COVID-19 and solid tumor development, urging further investigation.

Area of Science:

  • Oncology
  • Virology
  • Hepatology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is a type of non-Hodgkin lymphoma.
  • Primary hepatic DLBCL, originating in the liver, is exceptionally rare.
  • Recent research explores potential links between viral infections and cancer development.

Observation:

  • A 53-year-old male presented with fatigue and weight loss.
  • Diagnostic workup revealed elevated liver enzymes and multiple low-density liver lesions.
  • The patient had a history of prolonged coronavirus disease 2019 (COVID-19) four months prior to symptom onset.

Findings:

  • Liver biopsy with immunohistochemical analysis confirmed primary hepatic diffuse large B cell lymphoma (DLBCL).
  • This case represents a rare instance of DLBCL presenting solely within the liver.
  • The temporal association suggests a possible, though unconfirmed, role of COVID-19 in DLBCL development.

Implications:

  • This case underscores the importance of considering COVID-19 as a potential factor in the emergence of solid tumors.
  • Further research is crucial to elucidate the relationship between COVID-19 and oncogenesis.
  • Increased awareness and documentation of such cases are vital for understanding long-term health consequences of COVID-19.

Keywords:
COVID-19DLBCLoncogenic features of COVID 19primary hepatic lymphoma

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