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Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Related Experiment Video

Updated: Jul 4, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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MANEC TUMOR OF RECTUM. A RARE CASE SERIES OF 3 PATIENTS AND A LITERATURE REVIEW.

R Govindaraj1, Sh Govindaraj2, C Prakash2

  • 1MBBS, RajaRajeswari Medical College and Hospital (RRMCH), Bangalore, Karnataka, India.

Experimental Oncology
|February 8, 2024
PubMed
Summary

Mixed Adeno-Neuro-Endocrine Carcinoma (MANEC) is a rare rectal tumor. This study reviews three cases, detailing their presentation, diagnosis, and treatment for this uncommon malignancy.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Mixed Adeno-Neuro-Endocrine Carcinoma (MANEC) is a rare tumor defined by the WHO Classification of Tumors of the Digestive System.
  • MANEC features dual epithelial and neuroendocrine differentiation, with each component comprising at least 30% of the tumor.
  • This uncommon malignancy accounts for less than 3% of all colon and rectum cancers.

Conclusions:

  • MANEC of the rectum is an exceptionally rare entity.
  • Comprehensive diagnostic workup is crucial for accurate staging and treatment planning.
  • Further research into the clinical behavior and optimal management of MANEC is warranted given its rarity.