Equine uveitis: Outcome and adverse effects after one or two intravitreal low-dose gentamicin injections
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View abstract on PubMed
Summary
This summary is machine-generated.Intravitreal injections with low-dose gentamicin (IVGI) in horses with chronic uveitis showed a 41% positive outcome rate. However, complications like retinal degeneration occurred in 22% of eyes, necessitating careful consideration of this treatment.
Area Of Science
- Veterinary Ophthalmology
- Equine Medicine
- Pharmacology
Background
- Chronic uveitis in horses can lead to vision impairment or blindness.
- Current treatments often require long-term medication with potential side effects.
- Intravitreal injections with low-dose gentamicin (IVGI) are explored for sustained uveitis management in horses.
Purpose Of The Study
- To evaluate the outcomes and long-term complications of low-dose intravitreal gentamicin injections (IVGI) in Swedish horses with chronic uveitis.
- To assess the efficacy of one or two IVGI treatments for managing equine chronic uveitis.
Main Methods
- Retrospective case series of horses diagnosed with chronic uveitis between 2016 and 2021.
- Inclusion criteria: horses treated with 4mg IVGI, with some receiving a second injection for persistent uveitis.
- Positive outcome defined as controlled uveitis with minimal or no anti-inflammatory medication.
Main Results
- 41% (13/32 eyes) of horses achieved a positive outcome after one or two IVGI treatments.
- Complications included retinal degeneration (22% of eyes) and mature cataracts (15.6% of eyes).
- Enucleation was performed in 14/32 eyes due to treatment failure or complications; one horse was euthanized.
Conclusions
- Low-dose IVGI resulted in a positive outcome in 41% of treated equine eyes, predominantly with anterior uveitis.
- Retinal degeneration was a notable complication, observed in a higher proportion (22%) than previously reported.
- Limitations include small sample size, retrospective design, and lack of a control group.
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