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Naltrexone: its clinical utility.

H M Ginzburg

    Advances in Alcohol & Substance Abuse
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Naltrexone, an opioid antagonist, aids outpatient treatment for opioid abuse when combined with comprehensive therapy. It helps motivated patients manage addiction by supporting a non-opioid treatment plan.

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    Area of Science:

    • Pharmacology
    • Addiction Medicine
    • Clinical Therapeutics

    Background:

    • Opioid abuse presents significant medical, psychological, and economic challenges.
    • Naltrexone is an orally administered, long-acting opioid antagonist.
    • Current treatment approaches require comprehensive patient management.

    Purpose of the Study:

    • To evaluate the clinical utility of naltrexone as an adjunct in outpatient opioid abuse treatment.
    • To identify patient characteristics that predict successful naltrexone therapy.
    • To underscore the importance of naltrexone within a broader therapeutic framework.

    Main Methods:

    • Naltrexone administration regimens (daily, twice weekly, thrice weekly) are determined by clinical needs and therapeutic goals.
    • Physician prescription is facilitated as naltrexone is unscheduled under the Controlled Substances Act.

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  • Patient selection focuses on highly motivated individuals with specific demographic and treatment histories.

    • Main Results:

    • Naltrexone demonstrates clinical utility as an adjunct therapy for opioid abuse.
    • Successful outcomes are associated with patients who are employed, married, detoxified, and highly motivated.
    • Naltrexone facilitates separation from drug-using social circles and supports engagement in therapeutic activities.

    Conclusions:

    • Naltrexone is a valuable tool for clinicians managing opioid abuse, particularly for highly motivated patients.
    • It does not cure opioid dependency but assists in addressing associated problems.
    • Optimal efficacy of naltrexone is achieved when integrated into a personalized, comprehensive treatment regimen.