Electrochemical Oxidative Dearomatization Strategy for Accessing Spiro[4.5]dienones and Derivatives
Rohan Bag1, Nilima Priyadarsini Mishra1, Debarshi Saha1
1Lab No. 406, Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Abstract:
Electrochemical dearomatization has been recognized as an attractive tool for the rapid construction of structurally diverse molecules. The designed methodology encompasses an eco-friendly and efficient electrochemical approach to synthesizing spiro[4.5]dienones under mild reaction conditions. Furthermore, detailed mechanistic studies strongly bolster our hypothesis and emphasize the role of HFIP in the mechanism. The protocol is scalable and showcases a broad substrate scope with tolerance toward numerous functional groups. Henceforth, this strategy can be deployed as an alternative and sustainable tool for accessing spiro[4.5]dienones.
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