Related Experiment Video
Updated: Jul 4, 2025

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
Published on: February 21, 2025
The multiple facets of the club cell in the pulmonary epithelium
Nelly López-Valdez1, Marcela Rojas-Lemus1, Patricia Bizarro-Nevares1
1Department of Cellular and Tisular Biology, School of Medicine, UNAM, Ciudad de México, México.
Abstract:
The non-ciliated bronchiolar cell, also referred to as "club cell", serves as a significant multifunctional component of the airway epithelium. While the club cell is a prominent epithelial type found in rodents, it is restricted to the bronchioles in humans. Despite these differences, the club cell's importance remains undisputed in both species due to its multifunctionality as a regulatory cell in lung inflammation and a stem cell in lung epithelial regeneration. The objective of this review is to examine different aspects of club cell morphology and physiology in the lung epithelium, under both normal and pathological conditions, to provide a comprehensive understanding of its importance in the respiratory system.
More Related Videos
09:27Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
Published on: May 6, 2020
06:27Author Spotlight: Modeling Human Airway Remodeling and Viral Responses Using Isogenic Epithelial, Endothelial, and Immune Cells
Published on: December 6, 2024
Related Concept Videos
Alveoli and Alveolar Ducts
Classification of Epithelial Tissues: Simple Epithelium
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
The Bronchial Tree
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Classification of Epithelial Tissues: Overview
Based on the number of cell layers,...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Epithelial Tissues and Their Functions
Epithelial tissues provide the body's first line of protection from physical,...