Visible light-promoted difluoromethylthiolation of cycloalkanols by C-C bond cleavage
1School of Science, Xichang University, Xichang 615000, P. R. China. hdss2006@163.com.
Abstract:
A mild and general methodology for the difluoromethylthiolation of cycloalkanols has been developed by employing N-difluoromethylthiophthalimide as the SCF2H radical source, in combination with an acridinium-derived organo-photosensitizer, under redox-neutral conditions. This reaction protocol demonstrates high efficiency, scalability, and mild reaction conditions, thus presenting a green approach for the rapid synthesis of distal difluoromethylthiolated alkyl ketones that are challenging to be synthesized through alternative means.
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