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Sodium-iodide symporter and its related solute carriers in thyroid cancer

Zhongqin Gong1, Minghui Wei2, Alexander C Vlantis1

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

The Journal of Endocrinology
|February 8, 2024
PubMed

Insights

Solute carrier (SLC) proteins, including the sodium-iodide symporter (NIS), are crucial in thyroid cancer development. Targeting these transporters offers a promising therapeutic strategy for thyroid cancer treatment.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Solute carrier (SLC) proteins are vital membrane transporters implicated in various diseases.
  • Dysfunction of SLC proteins plays a significant role in the pathogenesis of thyroid cancer.
  • The sodium-iodide symporter (NIS), also known as solute carrier family 5 member 5 (SLC5A5), is a key SLC member in thyroid cancer.

Purpose of the Study:

  • To explore the role of SLC members in thyroid cancer.
  • To investigate the potential of targeting SLC members as a therapeutic strategy for thyroid cancer.

Main Methods:

  • Review of existing literature on SLC family proteins and thyroid cancer.
  • Analysis of the known functions of NIS and other SLC members in thyroid cancer cell biology.

Main Results:

  • NIS dysregulation is well-documented in thyroid cancer, impacting radioactive iodide (RAI) therapy efficacy.
  • Other SLC members influence critical cellular processes like autophagy, proliferation, and apoptosis in thyroid cancer cells.
  • Altered expression of SLC members affects chemical uptake by thyroid cells.

Conclusions:

  • SLC family proteins are implicated in thyroid cancer pathogenesis and progression.
  • Targeting SLC members presents a promising therapeutic avenue for thyroid cancer treatment.
  • Further research into SLC family functions could lead to novel treatment strategies for thyroid cancer.
Keywords:
NISSLC5A5iodidesolute carrier familythyroid cancer

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