Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Acute poisoning by orphenadrine].

J Elmalem, R Garnier, R Nguyen Huu Chieu

    Annales De Medecine Interne
    |January 1, 1985
    PubMed
    Summary

    This study found an underestimated incidence of orphenadrine drug abuse, noting common symptoms like drowsiness, agitation, and anticholinergic effects. Severe cardiac issues were not observed in these poisoning cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of wave overtopping estimation models for urban beaches. Towards an early warning system on the Basque coast.

    The Science of the total environment·2023
    Same author

    Social association predicts immunological similarity in rewilded mice.

    bioRxiv : the preprint server for biology·2023
    Same author

    Poisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers.

    Clinical toxicology (Philadelphia, Pa.)·2018
    Same author

    Robust extraction of quantitative structural information from high-variance histological images of livers from necropsied Soay sheep.

    Royal Society open science·2017
    Same author

    Physiological proteins in resource-limited herbivores experiencing a population die-off.

    Die Naturwissenschaften·2017
    Same author

    Toxicodynetics in nordiazepam and oxazepam overdoses.

    Annales pharmaceutiques francaises·2017

    Area of Science:

    • Pharmacology
    • Toxicology
    • Clinical Medicine

    Context:

    • The Paris Poison Control Centre documented 84 cases of orphenadrine overdosage between 1974 and 1983.
    • Previous research primarily focused on fatalities associated with orphenadrine poisoning.

    Purpose:

    • To investigate the incidence and clinical presentation of orphenadrine overdosage.
    • To highlight the potential for anticholinergic drug abuse.

    Summary:

    • The study reviewed 84 cases of orphenadrine overdosage, revealing a clinical picture including drowsiness, agitation, confusion, delirium, and seizures.
    • Common anticholinergic symptoms observed were mydriasis, sinus tachycardia, dry mouth, and urinary retention.
    • Notably, no severe cardiac disturbances were reported in the studied patients.

    Impact:

    • Suggests a potentially underestimated prevalence of anticholinergic drug abuse.
    • Provides insights into the clinical manifestations of orphenadrine poisoning.
    • Informs clinical recognition and management of orphenadrine-related toxicity.

    Related Experiment Videos