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Updated: May 1, 2026
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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New Directions in Infection-Associated Ischemic Stroke
Jin-Man Jung1, András Gruber2, Peter Heseltine3
1Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea; Korea University Zebrafish, Translational Medical Research Center, Ansan, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|February 8, 2024
Summary
Infections can trigger strokes through various mechanisms. Identifying specific biomarkers like fibrin D-dimer is crucial for developing targeted therapies for infection-associated stroke.
Area of Science:
- Neurology
- Infectious Diseases
- Cardiovascular Science
Background:
- The link between infections and stroke is not fully understood, hindering targeted treatment development.
- Infections may contribute to stroke through hypercoagulability, endothelial dysfunction, vasculitis, and impaired thrombolysis.
- COVID-19 (caused by SARS-CoV-2) is associated with stroke, its most severe neurological complication.
Purpose of the Study:
- To review the mechanisms linking infections to stroke.
- To discuss challenges in developing specific therapies for infection-associated stroke.
- To explore the role of biomarkers in distinguishing causative infections from incidental ones.
Main Methods:
- This study is a narrative review of existing literature.
- It examines proposed pathophysiological mechanisms of infection-induced stroke.
- It discusses potential biomarkers for identifying pathogenic infections.
Main Results:
- Infections can precipitate stroke via hypercoagulability, endothelial dysfunction, vasculitis, and impaired thrombolysis.
- Distinguishing causative infections from incidental infections is a key challenge.
- Elevated fibrin D-dimer and anticardiolipin/antiphospholipid antibodies are candidate biomarkers.
Conclusions:
- Understanding infection-stroke mechanisms is vital for therapeutic advancement.
- Biomarkers like fibrin D-dimer may help identify infections that trigger stroke.
- Identifying pathogenic infections is a prerequisite for developing specific therapies for infection-associated stroke.
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