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Novel Heterogeneous Hydrogel with Dual-Responsive Shape Programmability and Good Biocompatibility.

Suyang Dai1, Lingchen Mao1, Huijuan Ning2

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

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|February 8, 2024
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Summary

This study introduces a novel dual-responsive hydrogel (PU-PAM/Alg/PDA) with thermal and ion responsiveness. This shape memory polymer exhibits complex shape morphing and reconfiguration, showing potential for biomedical applications like esophageal stents.

Keywords:
dual-responsiveheterogeneoushydrogelprogrammableshape memory polymers

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Shape memory polymers (SMPs) offer complex shape transformations but integrating multiple stimuli-responsiveness is challenging.
  • Existing multi-responsive materials often require intricate molecular designs and synthesis.

Purpose of the Study:

  • To design and synthesize a novel dual-responsive heterogeneous hydrogel (PU-PAM/Alg/PDA).
  • To investigate the thermal and ion responsiveness of the hydrogel.
  • To evaluate its potential as an esophageal stent.

Main Methods:

  • In situ free radical polymerization of acrylamide (AM) within a polyurethane foam (PU-foam) containing alginate (Alg) and polydopamine (PDA).
  • Utilizing polycaprolactone (PCL) melting-crystallization for thermal response.
  • Employing alginate-Fe3+ metallo-supramolecular interactions for ion response.
  • Assessing interfacial adhesion via PDA-polyurethane hydrogen bonding.

Main Results:

  • The PU-PAM/Alg/PDA hydrogel demonstrated dual responsiveness (thermal and ionic).
  • The material exhibited complex shape-morphing and permanent shape reconfiguration.
  • Enhanced interfacial adhesion resulted in excellent mechanical properties and structural integrity.
  • In vitro and in vivo tests confirmed good biocompatibility.

Conclusions:

  • The developed dual-responsive hydrogel offers a simplified approach to multi-stimuli materials.
  • The material's properties support its potential application as an esophageal stent.
  • The study highlights the successful integration of thermal and ionic responsiveness for advanced material design.