Cadmium-induced alterations in the Siberian hamster epididymis

The epididymis of sexually mature Siberian hamsters was found to consist of eight histologically distinct zones that were similar, in most respects, to those reported for other species. The notable exception to this is the presence of two types of tubules in zone 6; the typical major tubules predominate but are accompanied by smaller, contiguous, minor tubules. Following a single parenteral injection of cadmium chloride, the testes became necrotic and exhibited generalized sloughing of the seminiferous epithelium. The epididymis, on the other hand, retained their integrity following cadmium administration, although foci of degenerating cells were observed in the more proximal portions of the organ--i.e., zones 1-3. Vacular compromise is believed to be responsible for these necroses because of the severe edematous changes observed in the interstitial spaces. Evidence is presented for the localized degradation and elimination of necrotic cells from the testes as well as the epididymis.