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AcousticRobots: Smart acoustically powered micro-/nanoswimmers for precise biomedical applications.

Gege Wu1, Wei Xian2, Qing You3

  • 1Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore; Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Advanced Drug Delivery Reviews
|February 8, 2024
PubMed
Summary

Ultrasonic micro/nanorobots offer a promising solution for efficient biomedical delivery, overcoming limitations of current nanotechnology. These "AcousticRobots" leverage ultrasound for controlled movement and targeted therapeutic applications.

Keywords:
BiomedicineMicrobubblesNanorobotUltrasound

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Acoustic Robotics

Background:

  • Nanotechnology faces challenges in efficient biomedical delivery for therapeutic applications.
  • Ultrasound offers deep penetration and controlled actuation for micro/nanoswimmers.
  • Recent advances enable enhanced functionality and potential for medical use.

Purpose of the Study:

  • To review ultrasonic micro/nanorobots (AcousticRobots) for biomedical applications.
  • To summarize mechanisms, design, fabrication, and control of AcousticRobots.
  • To highlight applications and future challenges in the field.

Main Methods:

  • Review of mechanisms of AcousticRobots and their interaction with acoustic fields.
  • Discussion of design considerations: components, size, shape, and synthetic methods.
  • Exploration of surface modification, controllable behaviors, and hybrid propulsion integration.

Main Results:

  • AcousticRobots demonstrate potential for efficient drug delivery and targeted therapies.
  • Applications include cell manipulation, diagnostics, imaging, and minimally invasive surgery.
  • Integration with hybrid propulsion enhances functionality and control.

Conclusions:

  • AcousticRobots represent a significant advancement in active biomedical delivery platforms.
  • Further research is needed to address challenges and optimize clinical translation.
  • The field holds substantial promise for revolutionizing medical treatments.