Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Kurtis F Budden1, Shakti D Shukla1, Kate L Bowerman2
1Priority Research Centre for Healthy Lungs and Immune Health Research Program, The University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia.
Gut
|February 8, 2024
Summary
The gut microbiome plays a role in chronic obstructive pulmonary disease (COPD) development. Modulating the gut microbiota with complex carbohydrates can improve COPD symptoms and lung function.
Area of Science:
- Microbiology
- Pulmonology
- Gastroenterology
Background:
- Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality, with pathogenesis poorly understood, hindering effective treatments.
- The gut-lung axis suggests a link between the gastrointestinal microbiome and chronic lung diseases, but its specific role in COPD is unclear.
Purpose of the Study:
- To investigate the role of the gut microbiome in cigarette smoke (CS)-induced COPD.
- To explore the therapeutic potential of targeting the gut microbiome in COPD.
Main Methods:
- Utilized a mouse model of CS-induced COPD and fecal microbial transfer (FMT).
- Employed metagenomics, proteomics, and metabolomics to characterize the gut microbiota.
- Assessed complex carbohydrate interventions in mice and human COPD patients.
Main Results:
- Fecal microbial transfer ameliorated COPD features, including inflammation, lung damage, and impaired lung function.
- Gut microbiota alterations were linked to specific bacterial families (Muribaculaceae, Desulfovibrionaceae, Lachnospiraceae).
- Complex carbohydrate supplementation improved COPD outcomes in both mice and human patients.
Conclusions:
- The gut microbiome is a significant contributor to COPD pathogenesis.
- Targeting the gut microbiome, particularly with complex carbohydrates, offers a potential therapeutic strategy for COPD.
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