Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
pH Scale02:41

pH Scale

68.9K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
68.9K
Polyprotic Acids03:38

Polyprotic Acids

29.2K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
29.2K
Stomach pH Regulation01:21

Stomach pH Regulation

6.0K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
6.0K
pH01:24

pH

133.7K
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium...
133.7K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Vaginal Ph Value Can Affect The Susceptibility To Human Papillomavirus Infection

Vaginal pH value can affect the susceptibility to human papillomavirus infection

Yinxia Liu1,2, Zhengyu Li3,4

  • 1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, No. 20 Section 3, Renmin South Road, Chengdu, Sichuan, 610041, People's Republic of China.

BMC Infectious Diseases
|February 8, 2024

Related Experiment Videos

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
08:15

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

2.3K
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.2K
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
12:34

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

19.2K

View abstract on PubMed

Summary
This summary is machine-generated.

Elevated vaginal pH increases susceptibility to human papillomavirus (HPV) infection by affecting viral adherence to cells. This finding highlights pH as a factor in HPV infection risk.

Area of Science:

  • Gynecology
  • Virology
  • Oncology

Background:

  • Cervical cancer, a leading cancer in women, is primarily caused by persistent high-risk human papillomavirus (HPV) infections.
  • Vaginal pH, normally maintained between 3.8-4.5 in pre-menopausal women, can be influenced by various factors.
  • Previous research suggests a link between vaginal pH and HPV infection susceptibility.

Purpose of the Study:

  • To investigate the relationship between vaginal pH and susceptibility to human papillomavirus (HPV) infection.
  • To explore the impact of pH on HPV pseudovirus (PsVs) infection in vitro and in vivo.

Main Methods:

  • Retrospective analysis of medical data from 3115 women undergoing leukorrhea examination.
  • Exclusion criteria included infectious diseases, cancer, pregnancy, recent delivery, and lack of recent HPV test results.
Keywords:
HPVHPV pseudoviruspH value

Related Experiment Videos

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
08:15

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

2.3K
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.2K
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
12:34

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

19.2K
  • In vitro and in vivo experiments using HPV pseudoviruses (PsVs) to assess pH effects on infection and viral adherence.

    • Main Results:

    • Higher percentages of HPV and high-risk HPV infections were observed in women with vaginal pH ≥5.0 compared to those with pH <5.0.
    • In vitro studies showed increased HPV PsVs infection rates in higher pH media, primarily due to enhanced viral adherence to cells.
    • In vivo experiments demonstrated greater HPV PsVs adherence to mouse vaginal epithelial cells as pH increased.

    Conclusions:

    • Vaginal pH is associated with HPV infection susceptibility.
    • pH influences HPV PsVs infection by affecting viral adherence to cells, both in vitro and in vivo.
    • Cell surface receptors Syndecan-1 and Integrin α6 do not appear to be pH-affected, suggesting other mechanisms require further investigation.