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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
Published on: February 14, 2021
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The most influential articles on stem cells in intervertebral disc degeneration
Shuxi Ye1, Rongchun Chen1, Jiangyou Shi2
1Department of Spine Surgery, Ganzhou People's Hospital, No 16, Meiguan Road, Ganzhou, 341099, China.
BMC Musculoskeletal Disorders
|February 8, 2024
Summary
This study analyzed the top 50 most-cited articles on stem cells for intervertebral disc degeneration (IDD). Bone marrow stem cells in humans were the most common focus, providing insights for future IDD regeneration research.
Area of Science:
- Regenerative Medicine
- Biomedical Engineering
- Orthopedics
Background:
- Stem cell research is crucial for intervertebral disc degeneration (IDD) regeneration.
- A comprehensive analysis of highly-cited stem cell studies in IDD is lacking.
- This study identifies and summarizes seminal research in stem cell-based IDD treatment.
Purpose of the Study:
- To identify and analyze the most influential, highly-cited research papers on stem cells for intervertebral disc degeneration (IDD).
- To provide a foundational understanding of key studies in the field of stem cell therapy for IDD.
- To guide future research directions in regenerative approaches for IDD.
Main Methods:
- Searched the Web of Science (WoS) database for stem cell and IDD-related articles.
- Identified and analyzed the 50 most-cited publications.
- Performed correlation analysis between WoS citations, Altmetric Attention Score (AAS), and Dimensions metrics.
Main Results:
- The top 50 papers received 92-370 citations.
- United States, China, and Japan led in publications.
- Bone marrow-derived stem cells in human studies were most prevalent.
- Spine and Biomaterials were the leading journals.
- High correlation observed between WoS and Dimensions citations (r=0.937).
Conclusions:
- This is the first assessment of the highest-impact articles on stem cells for IDD.
- The findings offer a historical perspective and understanding of key research in stem cell therapy for IDD.
- This review serves as a valuable resource for researchers advancing stem cell applications in IDD.
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