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A 3D printable tissue adhesive.

Sarah J Wu1, Jingjing Wu1, Samuel J Kaser2

  • 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Nature Communications
|February 8, 2024
PubMed
Summary
This summary is machine-generated.

A new 3D printable tissue adhesive offers versatile, conformable, and robust adhesion for wet and bleeding tissues. This advanced biomaterial enables programmable bioadhesive patches and devices for improved wound closure and tissue repair.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Sutures and staples are standard for tissue repair but have limitations.
  • Existing tissue adhesives (glues, hydrogels) lack versatility and design flexibility.
  • A need exists for advanced adhesives with programmable architectures and enhanced functionalities.

Purpose of the Study:

  • To develop a direct-ink-write 3D printable tissue adhesive.
  • To create customizable bioadhesive patches and devices with programmable architectures.
  • To evaluate the adhesive's performance in tissue sealing, adhesion strength, biocompatibility, and applicability to bleeding tissues.

Main Methods:

  • Fabrication of a 3D printable tissue adhesive using direct-ink-write technology.
  • Assessment of adhesion to wet tissues, conformability, stretchability, and biocompatibility.
  • In vivo testing on rat trachea and colon defect models to evaluate fluid-tight sealing and adhesion duration.
  • Incorporation of a blood-repelling hydrophobic matrix to address bleeding tissues.

Main Results:

  • The 3D printable adhesive demonstrated robust adhesion to wet tissues within seconds.
  • Printed bioadhesive patches provided fluid-tight sealing in vivo, maintaining adhesion for over 4 weeks.
  • The adhesive exhibited favorable biocompatibility and was conformable and stretchable.
  • Patches with a hydrophobic matrix successfully sealed actively bleeding tissues.

Conclusions:

  • A versatile 3D printable tissue adhesive platform has been developed.
  • This technology enables application-specific designs for programmable bioadhesive patches and devices.
  • The adhesive shows significant potential for wound closure, tissue sealing, and integration with tissue-interfacing devices.