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Genotype F of Echovirus 25 with multiple recombination pattern have been persistently and extensively circulating in

Xiaoyi Wang1,2, Jianping Cun3, Shikang Li4

  • 1Medical School, Anhui University of Science and Technology, Huainan, 232001, China.

Scientific Reports
|February 8, 2024
PubMed

Insights

Echovirus 25 (E25) molecular epidemiology reveals genotype F dominance in China, driven by unique recombination patterns and evolution. This study enhances understanding for E25 prevention and control strategies.

Area of Science:

  • Virology
  • Molecular Epidemiology
  • Public Health

Background:

  • Echovirus 25 (E25), an Enterovirus B species member, is linked to aseptic meningitis, viral meningitis, and acute flaccid paralysis.
  • Systematic studies on E25 molecular epidemiology, evolution, and recombination are scarce.
  • Understanding E25's genetic diversity and transmission is crucial for disease control.

Purpose of the Study:

  • To investigate the molecular epidemiology, evolution, and recombination of Echovirus 25 globally and in China.
  • To identify dominant genotypes and transmission routes of E25.
  • To elucidate the evolutionary mechanisms contributing to E25's prevalence.

Main Methods:

  • Phylogenetic analysis of 113 full-length VP1 sequences from worldwide E25 strains.
  • Analysis of E25 strains (n=18) isolated in China (2009-2018) via the HFMD surveillance network.
  • Recombination and selection pressure analyses were performed on E25 sequences.

Main Results:

  • E25 strains were classified into 9 genotypes (A-I) globally, with genotype F being dominant in mainland China.
  • The average nucleotide substitution rate for E25 was 6.08 × 10-3 substitutions/site/year.
  • Seventeen recombination patterns were identified, with genotype F showing 9 distinct patterns and a positive selection site in its capsid protein.

Conclusions:

  • Genotype F's dominance in China is potentially linked to its multiple recombination patterns and evolutionary characteristics.
  • The identified transmission routes and genetic diversity provide a basis for E25 prevention and control.
  • This research offers critical insights into Echovirus 25 epidemiology and evolution.

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