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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells

Hui Kwon Kim1,2,3,4, Goosang Yu1,2, Jinman Park1,2

  • 1Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Nature Biotechnology
|February 8, 2024
PubMed
Abstract

No abstract available in PubMed .

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RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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