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Updated: Jul 4, 2025

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
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PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

Meneka Rupasinghe1,2, Cristiana Bersaglieri1, Deena M Leslie Pedrioli1

  • 1Department of Molecular Mechanisms of Disease, DMMD, University of Zurich, 8057, Zurich, Switzerland.

EMBO Reports
|February 8, 2024
PubMed
Summary

PRAMEL7 reprograms advanced stem cells to a ground state by interacting with Cullin2 (CUL2). This interaction targets repressive chromatin regulators for degradation, restoring pluripotency gene expression.

Keywords:
Cullin 2Ground-state PluripotencyNuRDPRAMEL7UHRF1

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