ChromoTimeSystem--a new generation of coagulation analyses

A new system of reagents and a dedicated instrument for coagulation and fibrinolysis assays, the ChromoTimeSystem is described. All assays are performed in the Chromotimer, a microprocessor controlled 4 channel photometer which is connected to micro computer. Most of the reagents use chromogenic substrates. PT, APTT, fibrinogen, reptilase time and thrombin time are all performed with 25 microliters of sample and 250 microliters of reagent. Neither predilution nor preincubation steps are necessary improving these photometric assays in respect to practicability and speed compared to coagulometric techniques. The use of photometry in contrast to the varying physical principles of classical coagulation analysis will be a step forward into standardization.