Related Experiment Video
Updated: May 11, 2026

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
Published on: March 4, 2016
Safety and efficacy of combined dilation/stenting of venous abnormalities, including complete obstructions, during
William P Knapp1, Edward T O'Leary1, Brian Quinn1
1Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Concurrent lead extraction and venous stenting effectively treated complex venous obstructions in congenital heart disease patients. This combined procedure demonstrated safety and efficacy, even in cases of complete obstruction.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Congenital Heart Disease Management
Background:
- Management of transvenous leads in congenital heart disease (CHD) patients is challenging due to potential venous obstructions and shunts.
- Previous interventions often faced difficulties with complete venous obstructions.
Purpose of the Study:
- To evaluate the safety and efficacy of concurrent transvenous lead extraction and venous pathway dilation/stenting in CHD patients.
- To assess the combined procedure's effectiveness in resolving complex venous anomalies.
Main Methods:
- Retrospective review of eight patients undergoing concurrent lead extraction and venous recanalization (2017-2021).
- Procedures included dilation and stenting of vena cavae/baffles, addressing complete obstructions and other venous anomalies.
Main Results:
- All eight patients (median age 38.5 years) with CHD had complete lead extractions, with a median lead dwell time of 13.8 years.
- Three patients had complete venous obstructions, and interventions included stenting of innominate veins and femoral vessel recanalization.
- The median procedure time was 9.8 hours, with complications including transfusion and arrhythmia; no deaths or major vascular injuries occurred.
Conclusions:
- Concurrent lead extraction and venous dilation/stenting is an effective strategy for managing complex venous issues in CHD patients.
- This combined approach safely resolves complete venous obstructions associated with transvenous leads.
- Despite lengthy procedure times, the intervention offers a viable solution with minimal complications.
More Related Videos
Related Concept Videos
Cardiac Catheterization III: Left Heart Catheterization
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis III: Interprofessional Care

