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Generation of Self-assembled Vascularized Human Skin Equivalents
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Vitamin C, lactoferrin and elastin-Advancing the science.

Alan D Widgerow1, Mary E Ziegler2

  • 1Center for Tissue Engineering, University of California, Irvine, California, USA.

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|February 9, 2024
PubMed
Summary

Sodium ascorbate (SAC) and lactoferrin show a synergistic effect, significantly boosting tropoelastin and elastin fiber production. This combination enhances skin health more effectively than other formulations.

Keywords:
Vit C saltelastin conservinglactoferrinreactive oxygen species

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Area of Science:

  • Dermatology and cosmetic science
  • Biochemistry of extracellular matrix components

Background:

  • Sodium ascorbate (SAC) is known for elastin conservation.
  • Previous studies indicated SAC-containing formulations stimulate elastin development.
  • Lactoferrin was investigated for potential synergy with SAC in elastin stimulation.

Purpose of the Study:

  • To evaluate the synergistic effects of lactoferrin and SAC on elastogenesis.
  • To compare the efficacy of SAC and lactoferrin combination with a standard formulation (CEF).
  • To investigate the impact on tropoelastin and CD44 expression in an ex vivo skin model.

Main Methods:

  • Utilized an ex vivo human skin model from 2 donors.
  • Applied lactoferrin, SAC, their combination, and CEF topically for 7 days.
  • Assessed elastogenesis via immunofluorescence for Tropoelastin and CD44, with DAPI counterstaining.

Main Results:

  • SAC and lactoferrin demonstrated a significant synergistic effect on tropoelastin stimulation.
  • The combination resulted in intact, increased elastin fibers, unlike fragmented fibers seen with CEF.
  • SAC showed an additive effect on CD44, indicating increased hyaluronic acid presence.

Conclusions:

  • The combination of SAC and lactoferrin is responsible for additive elastin stimulation.
  • This formulation offers antioxidant benefits, collagen stimulation, and enhanced elastin stimulation.
  • Represents an advance in topical antioxidant formulations for skin health.